Diet Coke fans warned as more evidence shows it could increase the risk of ‘silent killer’

This "new study" is garbage. No attempt at allowing for demographic confounds was made. It's probably just another proof that poor people have worse health. I append the original journal article below

The new study, published in the Diabetes Journal, found people who consumed artificial sweeteners were more at risk to type 2 diabetes compared with those who didn't.

“The findings strengthen evidence that these additives may not be safe sugar alternatives,” the researchers wrote.

“[It also] provides important insights in the context of ongoing worldwide re-evaluation of artificial sweeteners by health authorities.”

The French scientists analysed the diets and health of 105,588 people for nine years.

By the end of the study, 972 participants had developed type 2 diabetes.

The experts found those who consumed between 16 and 18mg of artificial sweeteners per day had a 69 per cent higher chance of developing the condition than those who ate less.

While those who ate and drank aspartame-containing products specifically had a 63 per cent higher chance of developing the disease.

Artificial Sweeteners and Risk of Type 2 Diabetes in the Prospective NutriNet-Santé Cohort

Charlotte Debras et al.

To study the relationships between artificial sweeteners, accounting for all dietary sources(total and by type of artificial sweetener) and risk of type 2 diabetes (T2D), in a large-scale prospective cohort.

The analyses included 105,588 participants from the web-based NutriNet-Santé study (France, 2009–2022; mean age 42.5 ± 14.6 years, 79.2% women). Repeated 24-h dietary records, including brands and commercial names of industrial products, merged with qualitative and quantitative food additive composition data, enabled artificial sweetener intakes to be accurately assessed from all dietary sources. Associations between artificial sweeteners (total, aspartame, acesulfame potassium [K], and sucralose) and T2D were investigated using Cox proportional hazard models adjusted for potential confounders, including weight variation during follow-up.

During a median follow-up of 9.1 years (946,650 person-years, 972 incident T2D), compared with nonconsumers, higher consumers of artificial sweeteners (i.e., above the sex-specific medians of 16.4 mg/day in men and 18.5 mg/day in women) had higher risks of developing T2D (hazard ratio [HR] 1.69; 95% CI 1.45–1.97; P-trend <0.001). Positive associations were also observed for individual artificial sweeteners: aspartame (HR 1.63 [95% CI 1.38–1.93], P-trend <0.001), acesulfame-K (HR 1.70 [1.42–2.04], P-trend <0.001), and sucralose (HR 1.34 [1.07–1.69], P-trend = 0.013).

Potential for reverse causality cannot be eliminated; however, many sensitivity analyses were computed to limit this and other potential biases. These findings of positive associations between artificial sweetener intakes and increased T2D risk strengthen the evidence that these additives may not be safe sugar alternatives. This study provides important insights in the context of on-going reevaluation of artificial sweeteners by health authorities worldwide.


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